Perfil lipídico y relación monocito/HDL en pacientes con infarto agudo de miocardio admitidos en sala de cardiología del Hospital Regional Rafael Hernández, provincia de Chiriquí.: Lipid profile and monocyte-to-HDL ratio in patients with acute myocardial infarction admitted to the cardiology ward of the Hospital Regional Rafael Hernández,  Chiriquí province.

Franklin Anguizola; Jorge Serrano; Sofía E Serracín; Pilar E. Serracín; Margie Sanchéz

doi:10.59722/rmcu.v3i1.1001

Authors

Franklin Anguizola Médico Residente|Complejo Especializado Dr.Rafael Hernández L., Panamá https://orcid.org/0000-0002-7982-0284
Jorge Serrano Médico Residente|Complejo Especializado Dr.Rafael Hernández L., Panamá https://orcid.org/0009-0008-7515-9469
Sofía E Serracín Docente tiempo completo en la Facultad de Ingeniería eléctrica|Universidad Tecnológica de Panamá,Panamá https://orcid.org/0009-0006-5130-2000
Pilar E. Serracín Médico Interno|Complejo Especializado Dr.Rafael Hernández L., Panamá https://orcid.org/0009-0003-0200-5622
Margie Sanchéz Médico General en Sala de Cardiología|Complejo Especializado Dr.Rafael Hernández L., Panamá https://orcid.org/0009-0002-0099-452X

DOI:

https://doi.org/10.59722/rmcu.v3i1.1001

Keywords:

myocardial infarction, lipids, MHR, high-density lipoproteins, ST elevation myocardial infarction, non-ST elevation myocardial infarction, inflammation

Abstract

Introduction: Acute myocardial infarction (AMI) is a major cause of cardiovascular morbidity and mortality. The monocyte-to-HDL ratio (MHR) has emerged as a potential marker of residual inflammation.
Objective: To describe the lipid profile and evaluate the MHR in patients with AMI admitted to the cardiology ward of the Hospital Regional Rafael Hernández, Chiriquí, between April 2023 and October 2024.
Methods: Observational, descriptive, and cross-sectional study. A total of 140 patients with AMI (STEMI or NSTEMI) were included. Patients on statins at admission were excluded. Clinical, biochemical, and demographic variables were collected. MHR was calculated as the absolute monocyte count (10⁹/L) divided by HDL level (mmol/L). Groups were compared using Student’s t-test.
Results: The mean age was 64.3 years, with a male predominance (61.4%). STEMI was present in 57.1%, and NSTEMI in 42.9%. NSTEMI patients had lower HDL and higher triglycerides. MHR was significantly higher in the NSTEMI group (0.0187 ± 0.0138) compared to the STEMI group (0.0144 ± 0.0064), with p = 0.029.
Conclusion: MHR was significantly elevated in patients with NSTEMI, suggesting a greater inflammatory burden. This index may be useful for risk stratification and identifying candidates for anti-inflammatory therapies such as colchicine.

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